Pneumonia is a significant cause of death in sheep flocks. Thus, antibiotics are\nessential for the treatment of bacterial pneumonia to reduce morbidity and mortality, but few drugs\nare specifically labeled for clinical use in sheep. Many of the antimicrobial clinical prescriptions that\noccur in sheep are classified as extra-label use, with dosage, administration frequency, indications, and\ndrug withdrawal times usually being extrapolated from information reported in other species. Thus,\nthe objective of this study was to determine the disposition kinetics of tildipirosin after intravenous,\nintramuscular, and subcutaneous administration in sheep. Throughout the experiment, all ewes\nwere healthy and no adverse reactions were recorded. The apparent volume of distribution was\nhigh, indicating a wide distribution in the body, which can be attributed to a significant fraction\nof tildipirosin inside the cells, and its expected activity against intracellular bacteria. Following\nintramuscular administration, tildipirosin was rapidly absorbed even to a greater extent when\ncompared to subcutaneous administration. Most of the adsorbed tildipirosin after intramuscular and\nsubcutaneous administrations were available in the body (>70%). In brief, the excellent tolerability of\nthis formulation and the suitable disposition of tildipirosin in the body makes it an alternative for\nsheep use, in conditions where the administration of antibiotics is needed to observe desired effects\nwith the benefits of scant manipulation of animals.
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